Wolves would have been two up in the 15th minute were it not for Lee Grant, who made a good close-range block at the near post as Kightly met Ebanks-Blake's cross.
The visitors continued to look dangerous and George Friend headed just wide as he ran in to meet Dave Edwards' cross from the right. Edwards, who passed a fitness test on a thigh injury to play, lashed just wide with a shot from the edge of the area just before the half-hour mark.
At the other end, Jermaine Johnson was responsible for a woeful miss as Wednesday went on the counter-attack. Breaking from a Wolves corner, Johnson ran from the half-way line but after beating two defenders, he fired a poor effort way over the bar with only Wayne Hennessey to beat.